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Targeting myeloid-derived suppressor cells with colony stimulating factor-1 receptor blockade can reverse immune resistance to immunotherapy in indoleamine 2,3-dioxygenase-expressing tumors

Tumor indoleamine 2,3-dioxygenase (IDO) promotes immunosuppression by direct action on effector T cells and Tregs and through recruitment, expansion and activation of myeloid-derived suppressor cells (MDSCs). Targeting of MDSCs is clinically being explored as a therapeutic strategy, though optimal t...

詳細記述

保存先:
書誌詳細
出版年:EBioMedicine
主要な著者: Holmgaard, Rikke B., Zamarin, Dmitriy, Lesokhin, Alexander, Merghoub, Taha, Wolchok, Jedd D.
フォーマット: Artigo
言語:Inglês
出版事項: Elsevier 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856741/
https://ncbi.nlm.nih.gov/pubmed/27211548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2016.02.024
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