Influence of improved FcRn binding on the subcutaneous bioavailability of monoclonal antibodies in cynomolgus monkeys

由 Datta-Mannan, Amita, Witcher, Derrick R, Lu, Jirong, Wroblewski, Victor J
出版 2012

Structural basis of selectivity and neutralizing activity of a TGFα/epiregulin specific antibody

由 Boyles, Jeffrey S., Atwell, Shane, Druzina, Zhanna, Heuer, Josef G., Witcher, Derrick R.
發表在 Protein Sci (2016)

Generation and characterization of tabalumab, a human monoclonal antibody that neutralizes both soluble and membrane-bound B-cell activating factor

由 Manetta, Joseph, Bina, Holly, Ryan, Paul, Fox, Niles, Witcher, Derrick R, Kikly, Kristine
出版 2014

The interplay of non-specific binding, target-mediated clearance and FcRn interactions on the pharmacokinetics of humanized antibodies

由 Datta-Mannan, Amita, Lu, Jirong, Witcher, Derrick R, Leung, Donmienne, Tang, Ying, Wroblewski, Victor J
發表在 MAbs (2015)

Expression and Subunit Interaction of Voltage-Dependent Ca(2+) Channels in PC12 Cells

由 Liu, Hongyan, Felix, Ricardo, Gurnett, Christina A., De Waard, Michel, Witcher, Derrick R., Campbell, Kevin P.
發表在 J Neurosci (1996)

Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics

由 Datta-Mannan, Amita, Thangaraju, Arunkumar, Leung, Donmienne, Tang, Ying, Witcher, Derrick R, Lu, Jirong, Wroblewski, Victor J
發表在 MAbs (2015)

Neonatal Fc Receptor Mediates Internalization of Fc in Transfected Human Endothelial Cells

由 Goebl, Nancy A., Babbey, Clifford M., Datta-Mannan, Amita, Witcher, Derrick R., Wroblewski, Victor J., Dunn, Kenneth W.
出版 2008

Fas ligand-induced murine pulmonary inflammation is reduced by a stable decoy receptor 3 analogue

由 Wortinger, Mark A, Foley, Joseph W, Larocque, Patrick, Witcher, Derrick R, Lahn, Michael, Jakubowski, Joseph A, Glasebrook, Andrew, Song, Ho Yeong
出版 2003

Influence of physiochemical properties on the subcutaneous absorption and bioavailability of monoclonal antibodies

由 Datta-Mannan, Amita, Estwick, Selina, Zhou, Chen, Choi, Hiuwan, Douglass, Nicole E., Witcher, Derrick R., Lu, Jirong, Beidler, Catherine, Millican, Rohn
發表在 MAbs (2020)

Ghrelin octanoylation mediated by an orphan lipid transferase

由 Gutierrez, Jesus A., Solenberg, Patricia J., Perkins, Douglas R., Willency, Jill A., Knierman, Michael D., Jin, Zhaoyan, Witcher, Derrick R., Luo, Shuang, Onyia, Jude E., Hale, John E.
出版 2008

FcγRIIIa-dependent IFN-γ release in whole blood assay is predictive of therapeutic IgG1 antibodies safety

由 Alakhras, Nada S., Qiu, Jiabin, Rocha, Guilherme V., Witcher, Derrick R., Koester, Anja, You, Jinsam, Schaer, David A., Holmgaard, Rikke B., Driscoll, Kyla, Willy, Jeffrey A., Malherbe, Laurent P.
發表在 MAbs (2018)

Discovery and characterization of a neutralizing pan-ELR+CXC chemokine monoclonal antibody

由 Boyles, Jeffrey S., Beidler, Catherine B., Strifler, Beth A., Girard, Daniel S., Druzina, Zhanna, Durbin, Jim D., Swearingen, Michelle L., Lee, Linda N., Kikly, Kristine, Chintharlapalli, Sudhakar, Witcher, Derrick R.
發表在 MAbs (2020)

Hepcidin as a predictive factor and therapeutic target in erythropoiesis-stimulating agent treatment for anemia of chronic disease in rats

由 Theurl, Milan, Nairz, Manfred, Schroll, Andrea, Sonnweber, Thomas, Asshoff, Malte, Haschka, David, Seifert, Markus, Willenbacher, Wolfgang, Wilflingseder, Doris, Posch, Wilfried, Murphy, Anthony T., Witcher, Derrick R., Theurl, Igor, Weiss, Günter
發表在 Haematologica (2014)

A decoy receptor 3 analogue reduces localised defects in phagocyte function in pneumococcal pneumonia

由 Marriott, Helen M, Daigneault, Marc, Thompson, Alfred A R, Walmsley, Sarah R, Gill, Sharonjit K, Witcher, Derrick R, Wroblewski, Victor J, Hellewell, Paul G, Whyte, Moira K B, Dockrell, David H
出版 2012

Targeting the hepcidin–ferroportin pathway in anaemia of chronic kidney disease

由 Sheetz, Matthew, Barrington, Philip, Callies, Sophie, Berg, Paul H., McColm, Juliet, Marbury, Thomas, Decker, Brian, Dyas, Gregory L., Truhlar, Stephanie M.E., Benschop, Robert, Leung, Donmienne, Berg, Jolene, Witcher, Derrick R.
發表在 Br J Clin Pharmacol (2019)

Novel Ghrelin Assays Provide Evidence for Independent Regulation of Ghrelin Acylation and Secretion in Healthy Young Men

由 Liu, Jianhua, Prudom, Catherine E., Nass, Ralf, Pezzoli, Suzan S., Oliveri, Mary C., Johnson, Michael L., Veldhuis, Paula, Gordon, David A., Howard, Andrew D., Witcher, Derrick R., Geysen, H. Mario, Gaylinn, Bruce D., Thorner, Michael O.
出版 2008

Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels

由 Pichler, Irene, Minelli, Cosetta, Sanna, Serena, Tanaka, Toshiko, Schwienbacher, Christine, Naitza, Silvia, Porcu, Eleonora, Pattaro, Cristian, Busonero, Fabio, Zanon, Alessandra, Maschio, Andrea, Melville, Scott A., Grazia Piras, Maria, Longo, Dan L., Guralnik, Jack, Hernandez, Dena, Bandinelli, Stefania, Aigner, Elmar, Murphy, Anthony T., Wroblewski, Victor, Marroni, Fabio, Theurl, Igor, Gnewuch, Carsten, Schadt, Eric, Mitterer, Manfred, Schlessinger, David, Ferrucci, Luigi, Witcher, Derrick R., Hicks, Andrew A., Weiss, Günter, Uda, Manuela, Pramstaller, Peter P.
出版 2011