Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics

Lowering the isoelectric point (pI) through engineering the variable region or framework of an IgG can improve its exposure and half-life via a reduction in clearance mediated through non-specific interactions. As such, net charge is a potentially important property to consider in developing therape...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Datta-Mannan, Amita, Thangaraju, Arunkumar, Leung, Donmienne, Tang, Ying, Witcher, Derrick R, Lu, Jirong, Wroblewski, Victor J
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622971/
https://ncbi.nlm.nih.gov/pubmed/25695748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1016696
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados