Quantitative Prediction of Human Pharmacokinetics for mAbs Exhibiting Target-Mediated Disposition

Prediction of human pharmacokinetics (PK) can be challenging for monoclonal antibodies (mAbs) exhibiting target-mediated drug disposition (TMDD). In this study, we performed a quantitative analysis of a diverse set of six mAbs exhibiting TMDD to explore translational rules that can be utilized to pr...

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Dettagli Bibliografici
Pubblicato in:AAPS J
Autori principali: Singh, Aman P., Krzyzanski, Wojciech, Martin, Steven W., Weber, Gregory, Betts, Alison, Ahmad, Alaa, Abraham, Anson, Zutshi, Anup, Lin, John, Singh, Pratap
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer US 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4365083/
https://ncbi.nlm.nih.gov/pubmed/25445845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-014-9690-8
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