Localized oncolytic virotherapy inflames distant tumors and synergizes with immune checkpoint blockade leading to systemic tumor rejection

Eitemau Tebyg

• Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy
  gan: Zamarin, Dmitriy, et al.
  Cyhoeddwyd: (2014)
• Potentiation of immunomodulatory antibodies with oncolytic viruses for therapy of poorly-immunogenic tumors
  gan: Zamarin, Dmitriy, et al.
  Cyhoeddwyd: (2014)
• Targeting myeloid-derived suppressor cells with colony stimulating factor-1 receptor blockade can reverse immune resistance to immunotherapy in indoleamine 2,3-dioxygenase-expressing tumors
  gan: Holmgaard, Rikke B., et al.
  Cyhoeddwyd: (2016)
• Expression of indoleamine 2.3-dioxygenase by tumors induces local and systemic immunosuppressive effects in a murine melanoma model
  gan: Holmgaard, Rikke B, et al.
  Cyhoeddwyd: (2014)
• Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity
  gan: Zamarin, Dmitriy, et al.
  Cyhoeddwyd: (2017)