Disruption of PLZP in Mice Leads to Increased T-Lymphocyte Proliferation, Cytokine Production, and Altered Hematopoietic Stem Cell Homeostasis

Deregulated function of members of the POK (POZ and Krüppel) family of transcriptional repressors, such as promyelocytic leukemia zinc finger (PLZF) and B-cell lymphoma 6 (BCL-6), plays a critical role in the pathogenesis of acute promyelocytic leukemia (APL) and non-Hodgkin's lymphoma, respect...

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Detalhes bibliográficos
Main Authors: Piazza, Francesco, Costoya, José A., Merghoub, Taha, Hobbs, Robin M., Pandolfi, Pier Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC529048/
https://ncbi.nlm.nih.gov/pubmed/15542853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.23.10456-10469.2004
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