Disruption of Ini1 Leads to Peri-Implantation Lethality and Tumorigenesis in Mice

SNF5/INI1 is a component of the ATP-dependent chromatin remodeling enzyme family SWI/SNF. Germ line mutations of INI1 have been identified in children with brain and renal rhabdoid tumors, indicating that INI1 is a tumor suppressor. Here we report that disruption of Ini1 expression in mice results i...

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Autores principales: Guidi, Cynthia J., Sands, Arthur T., Zambrowicz, Brian P., Turner, Tod K., Demers, Delia A., Webster, William, Smith, Thomas W., Imbalzano, Anthony N., Jones, Stephen N.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2001
Materias:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC100281/
https://ncbi.nlm.nih.gov/pubmed/11313485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.10.3598-3603.2001
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