NEDD4-1 Is a Proto-Oncogenic Ubiquitin Ligase for PTEN

The tumor suppressor PTEN, a critical regulator for multiple cellular processes, is mutated or deleted frequently in various human cancers. Subtle reductions in PTEN expression levels have profound impacts on carcinogenesis. Here we show that PTEN level is regulated by ubiquitin-mediated proteasomal...

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Detalhes bibliográficos
Main Authors: Wang, Xinjiang, Trotman, Lloyd, Koppie, Theresa, Alimonti, Andrea, Gao, Zhonghua, Wang, Junru, Erdjument-Bromage, Hediye, Tempst, Paul, Cordon-Cardo, Carlos, Pandolfi, Pier Paolo, Jiang, Xuejun
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1828909/
https://ncbi.nlm.nih.gov/pubmed/17218260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2006.11.039
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