Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events

The mammalian target of rapamycin (mTOR) represents a critical signaling crossroad where pathways commonly disrupted in cancer converge. We report here that Rheb GTPase, the upstream activator of the mTOR complex 1 (mTORC1) is amplified in human prostate cancers. We demonstrate that Rheb overexpress...

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Autori principali: Nardella, Caterina, Chen, Zhenbang, Salmena, Leonardo, Carracedo, Arkaitz, Alimonti, Andrea, Egia, Ainara, Carver, Brett, Gerald, William, Cordon-Cardo, Carlos, Pandolfi, Pier Paolo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2008
Soggetti:
Research Communication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518820/
https://ncbi.nlm.nih.gov/pubmed/18708577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1699608
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