Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

Numerous studies have established a causal link between aberrant mammalian target of rapamycin (mTOR) activation and tumorigenesis, indicating that mTOR inhibition may have therapeutic potential. In this study, we show that rapamycin and its analogs activate the MAPK pathway in human cancer, in what...

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Bibliografiska uppgifter
Huvudupphovsmän: Carracedo, Arkaitz, Ma, Li, Teruya-Feldstein, Julie, Rojo, Federico, Salmena, Leonardo, Alimonti, Andrea, Egia, Ainara, Sasaki, Atsuo T., Thomas, George, Kozma, Sara C., Papa, Antonella, Nardella, Caterina, Cantley, Lewis C., Baselga, Jose, Pandolfi, Pier Paolo
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2008
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518073/
https://ncbi.nlm.nih.gov/pubmed/18725988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34739
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