Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

Numerous studies have established a causal link between aberrant mammalian target of rapamycin (mTOR) activation and tumorigenesis, indicating that mTOR inhibition may have therapeutic potential. In this study, we show that rapamycin and its analogs activate the MAPK pathway in human cancer, in what...

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Detalhes bibliográficos
Main Authors: Carracedo, Arkaitz, Ma, Li, Teruya-Feldstein, Julie, Rojo, Federico, Salmena, Leonardo, Alimonti, Andrea, Egia, Ainara, Sasaki, Atsuo T., Thomas, George, Kozma, Sara C., Papa, Antonella, Nardella, Caterina, Cantley, Lewis C., Baselga, Jose, Pandolfi, Pier Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518073/
https://ncbi.nlm.nih.gov/pubmed/18725988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34739
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