Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

Numerous studies have established a causal link between aberrant mammalian target of rapamycin (mTOR) activation and tumorigenesis, indicating that mTOR inhibition may have therapeutic potential. In this study, we show that rapamycin and its analogs activate the MAPK pathway in human cancer, in what...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Carracedo, Arkaitz, Ma, Li, Teruya-Feldstein, Julie, Rojo, Federico, Salmena, Leonardo, Alimonti, Andrea, Egia, Ainara, Sasaki, Atsuo T., Thomas, George, Kozma, Sara C., Papa, Antonella, Nardella, Caterina, Cantley, Lewis C., Baselga, Jose, Pandolfi, Pier Paolo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2008
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2518073/
https://ncbi.nlm.nih.gov/pubmed/18725988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34739
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