The APL Paradigm and the “Co-Clinical Trial” Project

Por Nardella, Caterina, Lunardi, Andrea, Patnaik, Akash, Cantley, Lewis C., Pandolfi, Pier Paolo
Publicado em 2011

Characterization of the Hepatitis C Virus NS2/3 Processing Reaction by Using a Purified Precursor Protein

Por Pallaoro, Michele, Lahm, Armin, Biasiol, Gabriella, Brunetti, Mirko, Nardella, Caterina, Orsatti, Laura, Bonelli, Fabio, Orrù, Stefania, Narjes, Frank, Steinkühler, Christian
Publicado em 2001

Differential expression of S6K2 dictates tissue-specific requirement for S6K1 in mediating aberrant mTORC1 signaling and tumorigenesis

Por Nardella, Caterina, Lunardi, Andrea, Fedele, Giuseppe, Clohessy, John G., Alimonti, Andrea, Kozma, Sara C., Thomas, George, Loda, Massimo, Pandolfi, Pier Paolo
Publicado em 2011

Translation-dependent mechanisms lead to PML upregulation and mediate oncogenic K-RAS-induced cellular senescence

Por Scaglioni, Pier Paolo, Rabellino, Andrea, Yung, Thomas M, Bernardi, Rosa, Choi, Sooyeon, Konstantinidou, Georgia, Nardella, Caterina, Cheng, Ke, Pandolfi, Pier Paolo
Publicado em 2012

Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events

Por Nardella, Caterina, Chen, Zhenbang, Salmena, Leonardo, Carracedo, Arkaitz, Alimonti, Andrea, Egia, Ainara, Carver, Brett, Gerald, William, Cordon-Cardo, Carlos, Pandolfi, Pier Paolo
Publicado em 2008

ETS genetic rearrangements do not initiate cancer in the prostate

Por Carver, Brett S, Tran, Jennifer, Chen, Zhenbang, Carracedo-Perez, Arkaitz, Alimonti, Andrea, Nardella, Caterina, Gopalan, Anuradha, Scardino, Peter T, Cordon-Cardo, Carlos, Gerald, William, Pandolfi, Pier Paolo
Publicado em 2009

Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate

Por Carver, Brett S, Tran, Jennifer, Gopalan, Anuradha, Chen, Zhenbang, Shaikh, Safa, Carracedo, Arkaitz, Alimonti, Andrea, Nardella, Caterina, Varmeh, Shohreh, Scardino, Peter T, Cordon-Cardo, Carlos, Gerald, William, Pandolfi, Pier Paolo
Publicado em 2009

Subtle variations in Pten dose determine cancer susceptibility

Por Alimonti, Andrea, Carracedo, Arkaitz, Clohessy, John G, Trotman, Lloyd C, Nardella, Caterina, Egia, Ainara, Salmena, Leonardo, Sampieri, Katia, Haveman, William J, Brogi, Edi, Richardson, Andrea L, Zhang, Jiangwen, Pandolfi, Pier Paolo
Publicado em 2010

Differential requirement of mTOR in post-mitotic tissues and tumorigenesis

Por Nardella, Caterina, Carracedo, Arkaitz, Alimonti, Andrea, Hobbs, Robin M., Clohessy, John G., Chen, Zhenbang, Egia, Ainara, Fornari, Alessandro, Fiorentino, Michelangelo, Loda, Massimo, Kozma, Sara C., Thomas, George, Cordon-Cardo, Carlos, Pandolfi, Pier Paolo
Publicado em 2009

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

Por Carracedo, Arkaitz, Ma, Li, Teruya-Feldstein, Julie, Rojo, Federico, Salmena, Leonardo, Alimonti, Andrea, Egia, Ainara, Sasaki, Atsuo T., Thomas, George, Kozma, Sara C., Papa, Antonella, Nardella, Caterina, Cantley, Lewis C., Baselga, Jose, Pandolfi, Pier Paolo
Publicado em 2008

Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence

Por Lin, Hui-Kuan, Chen, Zhenbang, Wang, Guocan, Nardella, Caterina, Lee, Szu-Wei, Chan, Chia-Hsin, Yang, Wei-Lei, Wang, Jing, Egia, Ainara, Nakayama, Keiichi I., Cordon-Cardo, Carlos, Teruya-Feldstein, Julie, Pandolfi, Pier Paolo
Publicado em 2010

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

Por Alimonti, Andrea, Nardella, Caterina, Chen, Zhenbang, Clohessy, John G., Carracedo, Arkaitz, Trotman, Lloyd C., Cheng, Ke, Varmeh, Shohreh, Kozma, Sara C., Thomas, George, Rosivatz, Erika, Woscholski, Rudiger, Cognetti, Francesco, Scher, Howard I., Pandolfi, Pier Paolo
Publicado em 2010

MUC1 IS A POTENTIAL TARGET FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIA STEM CELLS

Por Stroopinsky, Dina, Rosenblatt, Jacalyn, Ito, Keisuke, Mills, Heidi, Yin, Li, Rajabi, Hasan, Vasir, Baldev, Kufe, Turner, Luptakova, Katarina, Arnason, Jon, Nardella, Caterina, Levine, James D., Joyce, Robin, Galinsky, Ilene, Reiter, Yoram, Stone, Richard, Pandolfi, Pier Paolo, Kufe, Donald, Avigan, David
Publicado em 2013

Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer

Por Juvekar, Ashish, Burga, Laura N., Hu, Hai, Lunsford, Elaine P., Ibrahim, Yasir H., Balmañà, Judith, Rajendran, Anbazhagan, Papa, Antonella, Spencer, Katherine, Lyssiotis, Costas A., Nardella, Caterina, Pandolfi, Pier Paolo, Baselga, Jose, Scully, Ralph, Asara, John M., Cantley, Lewis C., Wulf, Gerburg M.
Publicado em 2012

Lrf suppresses prostate cancer through repression of a Sox9-dependent pathway for cellular senescence bypass and tumor invasion

Por Wang, Guocan, Lunardi, Andrea, Zhang, Jiangwen, Chen, Zhenbang, Ala, Ugo, Webster, Kaitlyn A., Tay, Yvonne, Gonzalez-Billalabeitia, Enrique, Egia, Ainara, Shaffer, David R., Carver, Brett, Liu, Xue-Song, Taulli, Riccardo, Kuo, Winston Patrick, Nardella, Caterina, Signoretti, Sabina, Cordon-Cardo, Carlos, Gerald, William L., Pandolfi, Pier Paolo
Publicado em 2013

A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer

Por Lunardi, Andrea, Ala, Ugo, Epping, Mirjam T., Salmena, Leonardo, Clohessy, John G., Webster, Kaitlyn A., Wang, Guocan, Mazzucchelli, Roberta, Bianconi, Maristella, Stack, Edward C., Lis, Rosina, Patnaik, Akash, Cantley, Lewis C., Bubley, Glenn, Cordon-Cardo, Carlos, Gerald, William L., Montironi, Rodolfo, Signoretti, Sabina, Loda, Massimo, Nardella, Caterina, Pandolfi, Pier Paolo
Publicado em 2013

Vulnerabilities of PTEN-p53-deficient prostate cancers to compound PARP/PI3K inhibition

Por González-Billalabeitia, Enrique, Seitzer, Nina, Song, Su Jung, Song, Min Sup, Patnaik, Akash, Liu, Xue-Song, Epping, Mirjam T., Papa, Antonella, Hobbs, Robin M., Chen, Ming, Lunardi, Andrea, Ng, Christopher, Webster, Kaitlyn A., Signoretti, Sabina, Loda, Massimo, Asara, John M., Nardella, Caterina, Clohessy, John G., Cantley, Lewis C., Pandolfi, Pier Paolo
Publicado em 2014