Translation-dependent mechanisms lead to PML upregulation and mediate oncogenic K-RAS-induced cellular senescence

Expression of oncogenic K-RAS in primary cells elicits oncogene-induced cellular senescence (OIS), a form of growth arrest that potently opposes tumourigenesis. This effect has been largely attributed to transcriptional mechanisms that depend on the p53 tumour suppressor protein. The PML tumour supp...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Scaglioni, Pier Paolo, Rabellino, Andrea, Yung, Thomas M, Bernardi, Rosa, Choi, Sooyeon, Konstantinidou, Georgia, Nardella, Caterina, Cheng, Ke, Pandolfi, Pier Paolo
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: WILEY-VCH Verlag 2012
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Research Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407947/
https://ncbi.nlm.nih.gov/pubmed/22359342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201200233
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