Translation-dependent mechanisms lead to PML upregulation and mediate oncogenic K-RAS-induced cellular senescence

Expression of oncogenic K-RAS in primary cells elicits oncogene-induced cellular senescence (OIS), a form of growth arrest that potently opposes tumourigenesis. This effect has been largely attributed to transcriptional mechanisms that depend on the p53 tumour suppressor protein. The PML tumour supp...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Scaglioni, Pier Paolo, Rabellino, Andrea, Yung, Thomas M, Bernardi, Rosa, Choi, Sooyeon, Konstantinidou, Georgia, Nardella, Caterina, Cheng, Ke, Pandolfi, Pier Paolo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: WILEY-VCH Verlag 2012
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407947/
https://ncbi.nlm.nih.gov/pubmed/22359342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201200233
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