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PML is induced by oncogenic ras and promotes premature senescence

Oncogenic ras provokes a senescent-like arrest in human diploid fibroblasts involving the Rb and p53 tumor suppressor pathways. To further characterize this response, we compared gene expression patterns between ras-arrested and quiescent IMR90 fibroblasts. One of the genes up-regulated during ras-i...

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Bibliographic Details
Main Authors: Ferbeyre, Gerardo, de Stanchina, Elisa, Querido, Emmanuelle, Baptiste, Nicole, Prives, Carol, Lowe, Scott W.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2000
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC316863/
https://ncbi.nlm.nih.gov/pubmed/10950866
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