INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53

The INK4a/ARF locus encodes upstream regulators of the retinoblastoma and p53 tumor suppressor gene products. To compare the impact of these loci on tumor development and treatment response, the Eμ–myc transgenic lymphoma model was used to generate genetically defined tumors with mutations in the IN...

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Detalhes bibliográficos
Main Authors: Schmitt, Clemens A., McCurrach, Mila E., de Stanchina, Elisa, Wallace-Brodeur, Rachel R., Lowe, Scott W.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 1999
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC317110/
https://ncbi.nlm.nih.gov/pubmed/10541553
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