INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53

The INK4a/ARF locus encodes upstream regulators of the retinoblastoma and p53 tumor suppressor gene products. To compare the impact of these loci on tumor development and treatment response, the Eμ–myc transgenic lymphoma model was used to generate genetically defined tumors with mutations in the IN...

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Veröffentlicht in:	Genes Dev
Hauptverfasser:	Schmitt, Clemens A., McCurrach, Mila E., de Stanchina, Elisa, Wallace-Brodeur, Rachel R., Lowe, Scott W.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Cold Spring Harbor Laboratory Press 1999
Schlagworte:	Research Paper
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317110/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10541553/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.20.2670
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