INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53
The INK4a/ARF locus encodes upstream regulators of the retinoblastoma and p53 tumor suppressor gene products. To compare the impact of these loci on tumor development and treatment response, the Eμ–myc transgenic lymphoma model was used to generate genetically defined tumors with mutations in the IN...
Uloženo v:
| Vydáno v: | Genes Dev |
|---|---|
| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Cold Spring Harbor Laboratory Press
1999
|
| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317110/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10541553/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.20.2670 |
| Tagy: |
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|