Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

Establishment of primary mouse embryo fibroblasts (MEFs) as continuously growing cell lines is normally accompanied by loss of the p53 or p19(ARF) tumor suppressors, which act in a common biochemical pathway. myc rapidly activates ARF and p53 gene expression in primary MEFs and triggers replicative...

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Autores principales: Zindy, Frederique, Eischen, Christine M., Randle, David H., Kamijo, Takehiko, Cleveland, John L., Sherr, Charles J., Roussel, Martine F.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 1998
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Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC317045/
https://ncbi.nlm.nih.gov/pubmed/9694806
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