Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis
Mdm2 harnesses the p53 tumor suppressor, yet loss of one Mdm2 allele in Mdm2(+/–) mice has heretofore not been shown to impair tumor development. Here we report that Mdm2 haplo-insufficiency profoundly suppresses lymphomagenesis in Eµ-myc transgenic mice. Mdm2(+/–)Eµ-myc transgenics had greatly prot...
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| Publicado no: | EMBO J |
|---|---|
| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151074/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12628936/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg133 |
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