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Apoptosis Triggered by Myc-Induced Suppression of Bcl-X(L) or Bcl-2 Is Bypassed during Lymphomagenesis

Enforced Bcl-2 expression inhibits Myc-induced apoptosis and cooperates with Myc in transformation. Here we report that the synergy between Bcl-2 and Myc in transforming hematopoietic cells in fact reflects a Myc-induced pathway that selectively suppresses the expression of the Bcl-X(L) or Bcl-2 ant...

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Bibliografiske detaljer
Main Authors: Eischen, Christine M., Woo, David, Roussel, Martine F., Cleveland, John L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2001
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC87232/
https://ncbi.nlm.nih.gov/pubmed/11438662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.21.15.5063-5070.2001
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