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Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis
Mdm2 harnesses the p53 tumor suppressor, yet loss of one Mdm2 allele in Mdm2(+/–) mice has heretofore not been shown to impair tumor development. Here we report that Mdm2 haplo-insufficiency profoundly suppresses lymphomagenesis in Eµ-myc transgenic mice. Mdm2(+/–)Eµ-myc transgenics had greatly prot...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2003
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC151074/ https://ncbi.nlm.nih.gov/pubmed/12628936 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg133 |
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