Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis

Mdm2 harnesses the p53 tumor suppressor, yet loss of one Mdm2 allele in Mdm2(+/–) mice has heretofore not been shown to impair tumor development. Here we report that Mdm2 haplo-insufficiency profoundly suppresses lymphomagenesis in Eµ-myc transgenic mice. Mdm2(+/–)Eµ-myc transgenics had greatly prot...

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Publié dans:	EMBO J
Auteurs principaux:	Alt, Jodi R., Greiner, Timothy C., Cleveland, John L., Eischen, Christine M.
Format:	Artigo
Langue:	Inglês
Publié:	Nature Publishing Group 2003
Sujets:	Articles
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151074/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12628936/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg133
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