Bax Loss Impairs Myc-Induced Apoptosis and Circumvents the Selection of p53 Mutations during Myc-Mediated Lymphomagenesis

The ARF and p53 tumor suppressors mediate Myc-induced apoptosis and suppress lymphoma development in Eμ-myc transgenic mice. Here we report that the proapoptotic Bcl-2 family member Bax also mediates apoptosis triggered by Myc and inhibits Myc-induced lymphomagenesis. Bax-deficient primary pre-B cel...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Eischen, Christine M., Roussel, Martine F., Korsmeyer, Stanley J., Cleveland, John L.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2001
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC99936/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11604501/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.21.22.7653-7662.2001
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