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c-Myc Augments Gamma Irradiation-Induced Apoptosis by Suppressing Bcl-X(L)
Alterations in MYC and p53 are hallmarks of cancer. p53 coordinates the response to gamma irradiation (γ-IR) by either triggering apoptosis or cell cycle arrest. c-Myc activates the p53 apoptotic checkpoint, and thus tumors overexpressing MYC often harbor p53 mutations. Nonetheless, many of these ca...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Microbiology
2003
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC230315/ https://ncbi.nlm.nih.gov/pubmed/14517295 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.20.7256-7270.2003 |
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