c-Myc Augments Gamma Irradiation-Induced Apoptosis by Suppressing Bcl-X(L)

Alterations in MYC and p53 are hallmarks of cancer. p53 coordinates the response to gamma irradiation (γ-IR) by either triggering apoptosis or cell cycle arrest. c-Myc activates the p53 apoptotic checkpoint, and thus tumors overexpressing MYC often harbor p53 mutations. Nonetheless, many of these ca...

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Main Authors: Maclean, Kirsteen H., Keller, Ulrich B., Rodriguez-Galindo, Carlos, Nilsson, Jonas A., Cleveland, John L.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2003
主題:
Cell Growth and Development
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC230315/
https://ncbi.nlm.nih.gov/pubmed/14517295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.20.7256-7270.2003
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