c-Myc Augments Gamma Irradiation-Induced Apoptosis by Suppressing Bcl-X(L)
Alterations in MYC and p53 are hallmarks of cancer. p53 coordinates the response to gamma irradiation (γ-IR) by either triggering apoptosis or cell cycle arrest. c-Myc activates the p53 apoptotic checkpoint, and thus tumors overexpressing MYC often harbor p53 mutations. Nonetheless, many of these ca...
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| Published in: | Mol Cell Biol |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Taylor & Francis
2003
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230315/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14517295/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.20.7256-7270.2003 |
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