p53-independent functions of the p19(ARF) tumor suppressor

The p19(ARF) tumor suppressor antagonizes Mdm2 to induce p53-dependent cell cycle arrest. Individual TKO (triple knock out) mice nullizygous for ARF, p53, and Mdm2 develop multiple tumors at a frequency greater than those observed in animals lacking both p53 and Mdm2 or p53 alone, demonstrating that...

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Bibliografski detalji
Glavni autori: Weber, Jason D., Jeffers, John R., Rehg, Jerold E., Randle, David H., Lozano, Guillermina, Roussel, Martine F., Sherr, Charles J., Zambetti, Gerard P.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2000
Teme:
Research Paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC316930/
https://ncbi.nlm.nih.gov/pubmed/10995391
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