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Disruption of the ARF–Mdm2–p53 tumor suppressor pathway in Myc-induced lymphomagenesis

Transgenic mice expressing the c-Myc oncogene driven by the immunoglobulin heavy chain enhancer (Eμ) develop B-cell lymphoma and exhibit a mean survival time of approximately 6 months. The protracted latent period before the onset of frank disease likely reflects the ability of c-Myc to induce a p53...

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Udgivet i:Genes Dev
Principais autores: Eischen, Christine M., Weber, Jason D., Roussel, Martine F., Sherr, Charles J., Cleveland, John L.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 1999
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317106/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10541552/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.20.2658
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