Disruption of the ARF–Mdm2–p53 tumor suppressor pathway in Myc-induced lymphomagenesis
Transgenic mice expressing the c-Myc oncogene driven by the immunoglobulin heavy chain enhancer (Eμ) develop B-cell lymphoma and exhibit a mean survival time of approximately 6 months. The protracted latent period before the onset of frank disease likely reflects the ability of c-Myc to induce a p53...
שמור ב:
| הוצא לאור ב: | Genes Dev |
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| Principais autores: | , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Cold Spring Harbor Laboratory Press
1999
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317106/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10541552/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.20.2658 |
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