E1A signaling to p53 involves the p19(ARF) tumor suppressor

The adenovirus E1A oncogene activates p53 through a signaling pathway involving the retinoblastoma protein and the tumor suppressor p19(ARF). The ability of E1A to induce p53 and its transcriptional targets is severely compromised in ARF-null cells, which remain resistant to apoptosis following seru...

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Autori principali: de Stanchina, Elisa, McCurrach, Mila E., Zindy, Frederique, Shieh, Sheau-Yann, Ferbeyre, Gerardo, Samuelson, Andrew V., Prives, Carol, Roussel, Martine F., Sherr, Charles J., Lowe, Scott W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 1998
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC317046/
https://ncbi.nlm.nih.gov/pubmed/9694807
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