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Arf tumor suppressor promoter monitors latent oncogenic signals in vivo
Induction of the Arf tumor suppressor gene by elevated thresholds of mitogenic signals activates a p53-dependent transcriptional response that triggers either growth arrest or apoptosis, thereby countering abnormal cell proliferation. Conversely, Arf inactivation is associated with tumor development...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2003
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC307670/ https://ncbi.nlm.nih.gov/pubmed/14665695 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2536808100 |
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