Arf tumor suppressor promoter monitors latent oncogenic signals in vivo
Induction of the Arf tumor suppressor gene by elevated thresholds of mitogenic signals activates a p53-dependent transcriptional response that triggers either growth arrest or apoptosis, thereby countering abnormal cell proliferation. Conversely, Arf inactivation is associated with tumor development...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2003
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC307670/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14665695/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2536808100 |
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