Arf tumor suppressor promoter monitors latent oncogenic signals in vivo

Induction of the Arf tumor suppressor gene by elevated thresholds of mitogenic signals activates a p53-dependent transcriptional response that triggers either growth arrest or apoptosis, thereby countering abnormal cell proliferation. Conversely, Arf inactivation is associated with tumor development...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Zindy, Frederique, Williams, Richard T., Baudino, Troy A., Rehg, Jerold E., Skapek, Stephen X., Cleveland, John L., Roussel, Martine F., Sherr, Charles J.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2003
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC307670/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14665695/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.2536808100
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares