Arf tumor suppressor promoter monitors latent oncogenic signals in vivo

Induction of the Arf tumor suppressor gene by elevated thresholds of mitogenic signals activates a p53-dependent transcriptional response that triggers either growth arrest or apoptosis, thereby countering abnormal cell proliferation. Conversely, Arf inactivation is associated with tumor development...

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Autors principals: Zindy, Frederique, Williams, Richard T., Baudino, Troy A., Rehg, Jerold E., Skapek, Stephen X., Cleveland, John L., Roussel, Martine F., Sherr, Charles J.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2003
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC307670/
https://ncbi.nlm.nih.gov/pubmed/14665695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2536808100
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