p53-independent functions of the p19(ARF) tumor suppressor

The p19(ARF) tumor suppressor antagonizes Mdm2 to induce p53-dependent cell cycle arrest. Individual TKO (triple knock out) mice nullizygous for ARF, p53, and Mdm2 develop multiple tumors at a frequency greater than those observed in animals lacking both p53 and Mdm2 or p53 alone, demonstrating that...

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發表在:	Genes Dev
Principais autores:	Weber, Jason D., Jeffers, John R., Rehg, Jerold E., Randle, David H., Lozano, Guillermina, Roussel, Martine F., Sherr, Charles J., Zambetti, Gerard P.
格式:	Artigo
語言:	Inglês
出版:	Cold Spring Harbor Laboratory Press 2000
主題:	Research Paper
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316930/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10995391/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.827300
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