p53-independent functions of the p19(ARF) tumor suppressor
The p19(ARF) tumor suppressor antagonizes Mdm2 to induce p53-dependent cell cycle arrest. Individual TKO (triple knock out) mice nullizygous for ARF, p53, and Mdm2 develop multiple tumors at a frequency greater than those observed in animals lacking both p53 and Mdm2 or p53 alone, demonstrating that...
Guardado en:
| Publicado en: | Genes Dev |
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| Autores principales: | , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Cold Spring Harbor Laboratory Press
2000
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316930/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10995391/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.827300 |
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