INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53
The INK4a/ARF locus encodes upstream regulators of the retinoblastoma and p53 tumor suppressor gene products. To compare the impact of these loci on tumor development and treatment response, the Eμ–myc transgenic lymphoma model was used to generate genetically defined tumors with mutations in the IN...
Sábháilte in:
| Foilsithe in: | Genes Dev |
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| Príomhchruthaitheoirí: | , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe / Cruthaithe: |
Cold Spring Harbor Laboratory Press
1999
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| Ábhair: | |
| Rochtain ar líne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC317110/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10541553/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.13.20.2670 |
| Clibeanna: |
Níl clibeanna ann, Bí ar an gcéad duine le clib a chur leis an taifead seo!
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