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bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

Inactivation of p53-dependent apoptosis promotes oncogenic transformation, tumor development, and resistance to many cytotoxic anticancer agents. p53 can transcriptionally activate bax, a bcl-2 family member that promotes apoptosis. To determine whether bax is required for p53-dependent apoptosis, t...

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Detaylı Bibliyografya
Asıl Yazarlar: McCurrach, Mila E., Connor, Thomas M. F., Knudson, C. Michael, Korsmeyer, Stanley J., Lowe, Scott W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences of the USA 1997
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC20090/
https://ncbi.nlm.nih.gov/pubmed/9122197
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