bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

Inactivation of p53-dependent apoptosis promotes oncogenic transformation, tumor development, and resistance to many cytotoxic anticancer agents. p53 can transcriptionally activate bax, a bcl-2 family member that promotes apoptosis. To determine whether bax is required for p53-dependent apoptosis, t...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	McCurrach, Mila E., Connor, Thomas M. F., Knudson, C. Michael, Korsmeyer, Stanley J., Lowe, Scott W.
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1997
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20090/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9122197/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.6.2345
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