bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis
Inactivation of p53-dependent apoptosis promotes oncogenic transformation, tumor development, and resistance to many cytotoxic anticancer agents. p53 can transcriptionally activate bax, a bcl-2 family member that promotes apoptosis. To determine whether bax is required for p53-dependent apoptosis, t...
Zapisane w:
| Wydane w: | Proc Natl Acad Sci U S A |
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| Główni autorzy: | , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
National Academy of Sciences
1997
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20090/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9122197/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.6.2345 |
| Etykiety: |
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