PML is induced by oncogenic ras and promotes premature senescence

Oncogenic ras provokes a senescent-like arrest in human diploid fibroblasts involving the Rb and p53 tumor suppressor pathways. To further characterize this response, we compared gene expression patterns between ras-arrested and quiescent IMR90 fibroblasts. One of the genes up-regulated during ras-i...

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Библиографические подробности

Опубликовано в::	Genes Dev
Главные авторы:	Ferbeyre, Gerardo, de Stanchina, Elisa, Querido, Emmanuelle, Baptiste, Nicole, Prives, Carol, Lowe, Scott W.
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Cold Spring Harbor Laboratory Press 2000
Предметы:	Research Paper
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316863/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10950866/
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