Translation-dependent mechanisms lead to PML upregulation and mediate oncogenic K-RAS-induced cellular senescence

Expression of oncogenic K-RAS in primary cells elicits oncogene-induced cellular senescence (OIS), a form of growth arrest that potently opposes tumourigenesis. This effect has been largely attributed to transcriptional mechanisms that depend on the p53 tumour suppressor protein. The PML tumour supp...

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Detalhes bibliográficos
Main Authors: Scaglioni, Pier Paolo, Rabellino, Andrea, Yung, Thomas M, Bernardi, Rosa, Choi, Sooyeon, Konstantinidou, Georgia, Nardella, Caterina, Cheng, Ke, Pandolfi, Pier Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2012
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3407947/
https://ncbi.nlm.nih.gov/pubmed/22359342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201200233
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