The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA

The ubiquitin-like SUMO proteins covalently modify protein substrates and regulate their functional properties. In a broad spectrum of cancers, the tumor suppressor PML undergoes ubiquitin-mediated degradation primed by CK2 phosphorylation. Here we report that the SUMO E3-ligase inhibitor PIAS1 regu...

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Detalhes bibliográficos
Main Authors: Rabellino, Andrea, Carter, Brandon, Konstantinidou, Georgia, Wu, Shwu-Yuan, Rimessi, Alessandro, Byers, Laureen A., Heymach, John V., Girard, Luc, Chiang, Cheng-Ming, Teruya-Feldstein, Julie, Scaglioni, Pier Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3342450/
https://ncbi.nlm.nih.gov/pubmed/22406621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-3159
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