The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA

The ubiquitin-like SUMO proteins covalently modify protein substrates and regulate their functional properties. In a broad spectrum of cancers, the tumor suppressor PML undergoes ubiquitin-mediated degradation primed by CK2 phosphorylation. Here we report that the SUMO E3-ligase inhibitor PIAS1 regu...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Rabellino, Andrea, Carter, Brandon, Konstantinidou, Georgia, Wu, Shwu-Yuan, Rimessi, Alessandro, Byers, Laureen A., Heymach, John V., Girard, Luc, Chiang, Cheng-Ming, Teruya-Feldstein, Julie, Scaglioni, Pier Paolo
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3342450/
https://ncbi.nlm.nih.gov/pubmed/22406621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-3159
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki