The Mouse Hospital and Its Integration in Ultra-Precision Approaches to Cancer Care

Por Clohessy, John G., Pandolfi, Pier Paolo
Publicado no Front Oncol (2018)

Found in translation of mTOR signaling

Por Clohessy, John G, Reschke, Markus, Pandolfi, Pier Paolo
Publicado em 2012

SPAR, a lncRNA encoded mTORC1 inhibitor

Por Matsumoto, Akinobu, Clohessy, John G., Pandolfi, Pier Paolo
Publicado no Cell Cycle (2017)

The pleiotropic role of non-coding genes in development and cancer

Por Pasut, Alessandra, Matsumoto, Akinobu, Clohessy, John G., Pandolfi, Pier Paolo
Publicado no Curr Opin Cell Biol (2016)

Role of aberrant PI3K pathway activation in gallbladder tumorigenesis

Por Lunardi, Andrea, Webster, Kaitlyn A., Papa, Antonella, Padmani, Bhavik, Clohessy, John G., Bronson, Roderick T., Pandolfi, Pier Paolo
Publicado em 2014

The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model

Por Cheng, Ke, Sportoletti, Paolo, Ito, Keisuke, Clohessy, John G., Teruya-Feldstein, Julie, Kutok, Jeffery L., Pandolfi, Pier Paolo
Publicado em 2010

Optimized RNA-targeting CRISPR/Cas13d technology outperforms shRNA in identifying functional circRNAs

Por Zhang, Yang, Nguyen, Tuan M., Zhang, Xiao-Ou, Wang, Limei, Phan, Tin, Clohessy, John G., Pandolfi, Pier Paolo
Publicado no Genome Biol (2021)

Npm1 is a haploinsufficient suppressor of myeloid and lymphoid malignancies in the mouse

Por Sportoletti, Paolo, Grisendi, Silvia, Majid, Samia M., Cheng, Ke, Clohessy, John G., Viale, Agnes, Teruya-Feldstein, Julie, Pandolfi, Pier Paolo
Publicado em 2008

Differential expression of S6K2 dictates tissue-specific requirement for S6K1 in mediating aberrant mTORC1 signaling and tumorigenesis

Por Nardella, Caterina, Lunardi, Andrea, Fedele, Giuseppe, Clohessy, John G., Alimonti, Andrea, Kozma, Sara C., Thomas, George, Loda, Massimo, Pandolfi, Pier Paolo
Publicado em 2011

The RNA Binding Protein ESRP1 Fine-Tunes the Expression of Pluripotency-Related Factors in Mouse Embryonic Stem Cells

Por Fagoonee, Sharmila, Bearzi, Claudia, Di Cunto, Ferdinando, Clohessy, John G., Rizzi, Roberto, Reschke, Markus, Tolosano, Emanuela, Provero, Paolo, Pandolfi, Pier Paolo, Silengo, Lorenzo, Altruda, Fiorella
Publicado em 2013

Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism

Por Chen, Ming, Wan, Lixin, Zhang, Jiangwen, Zhang, Jinfang, Mendez, Lourdes, Clohessy, John G., Berry, Kelsey, Victor, Joshua, Yin, Qing, Zhu, Yuan, Wei, Wenyi, Pandolfi, Pier Paolo
Publicado no Nat Commun (2018)

Characterization and analysis of the composition and dynamics of the mammalian riboproteome

Por Reschke, Markus, Clohessy, John G., Seitzer, Nina, Goldstein, Daniel P., Breitkopf, Susanne B., Schmolze, Daniel B., Ala, Ugo, Asara, John M., Beck, Andrew H., Pandolfi, Pier Paolo
Publicado em 2013

CAV1 - GLUT3 signaling is important for cellular energy and can be targeted by Atorvastatin in Non-Small Cell Lung Cancer

Por Ali, Azhar, Levantini, Elena, Fhu, Chee Wai, Teo, Jun Ting, Clohessy, John G., Goggi, Julian L., Wu, Chan-shuo, Chen, Leilei, Chin, Tan Min, Tenen, Daniel G
Publicado no Theranostics (2019)

Nanoformulation of Olaparib amplifies PARP inhibition and sensitizes PTEN/TP53-deficient prostate cancer to radiation

Por van de Ven, Anne L, Tangutoori, Shifalika, Baldwin, Paige, Qiao, Ju, Gharagouzloo, Codi, Seitzer, Nina, Clohessy, John G., Makrigiorgos, G. Mike, Cormack, Robert, Pandolfi, Pier Paolo, Sridhar, Srinivas
Publicado no Mol Cancer Ther (2017)

NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease

Por Rau, Rachel, Magoon, Daniel, Greenblatt, Sarah, Li, Li, Annesley, Colleen, Duffield, Amy S., Huso, David, McIntyre, Emily, Clohessy, John G., Reschke, Markus, Pandolfi, Pier Paolo, Small, Donald, Brown, Patrick
Publicado em 2013

Subtle variations in Pten dose determine cancer susceptibility

Por Alimonti, Andrea, Carracedo, Arkaitz, Clohessy, John G, Trotman, Lloyd C, Nardella, Caterina, Egia, Ainara, Salmena, Leonardo, Sampieri, Katia, Haveman, William J, Brogi, Edi, Richardson, Andrea L, Zhang, Jiangwen, Pandolfi, Pier Paolo
Publicado em 2010

Differential requirement of mTOR in post-mitotic tissues and tumorigenesis

Por Nardella, Caterina, Carracedo, Arkaitz, Alimonti, Andrea, Hobbs, Robin M., Clohessy, John G., Chen, Zhenbang, Egia, Ainara, Fornari, Alessandro, Fiorentino, Michelangelo, Loda, Massimo, Kozma, Sara C., Thomas, George, Cordon-Cardo, Carlos, Pandolfi, Pier Paolo
Publicado em 2009

An Integrated Genome Wide CRISPRa Approach to Functionalize IncRNAs in Drug Resistance

Por Bester, Assaf C., Lee, Jonathan D., Chavez, Alejandro, Lee, Yu-Ru, Nachmani, Daphna, Vora, Su, Victor, Joshua, Sauvageau, Martin, Rinn, John L., Provero, Paolo, Church, George M., Clohessy, John G., Pandolfi, Pier Paolo
Publicado no Cell (2018)

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

Por Alimonti, Andrea, Nardella, Caterina, Chen, Zhenbang, Clohessy, John G., Carracedo, Arkaitz, Trotman, Lloyd C., Cheng, Ke, Varmeh, Shohreh, Kozma, Sara C., Thomas, George, Rosivatz, Erika, Woscholski, Rudiger, Cognetti, Francesco, Scher, Howard I., Pandolfi, Pier Paolo
Publicado em 2010

In vivo role of INPP4B in tumor and metastasis suppression through regulation of PI3K/AKT signaling at endosomes

Por Chew, Chen Li, Lunardi, Andrea, Gulluni, Federico, Ruan, Daniel T., Chen, Ming, Salmena, Leonardo, Nishino, Michiya, Papa, Antonella, Ng, Christopher, Fung, Jacqueline, Clohessy, John G., Sasaki, Junko, Sasaki, Takehiko, Bronson, Roderick T., Hirsch, Emilio, Pandolfi, Pier Paolo
Publicado no Cancer Discov (2015)