In vivo role of INPP4B in tumor and metastasis suppression through regulation of PI3K/AKT signaling at endosomes

The phosphatases PTEN and INPP4B have been proposed to act as tumor suppressors by antagonizing PI3K/AKT signaling, and are frequently dysregulated in human cancer. While PTEN has been extensively studied, little is known about the underlying mechanisms by which INPP4B exerts its tumor suppressive f...

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Publicat a:Cancer Discov
Autors principals: Chew, Chen Li, Lunardi, Andrea, Gulluni, Federico, Ruan, Daniel T., Chen, Ming, Salmena, Leonardo, Nishino, Michiya, Papa, Antonella, Ng, Christopher, Fung, Jacqueline, Clohessy, John G., Sasaki, Junko, Sasaki, Takehiko, Bronson, Roderick T., Hirsch, Emilio, Pandolfi, Pier Paolo
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497843/
https://ncbi.nlm.nih.gov/pubmed/25883022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-1347
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