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In vivo role of INPP4B in tumor and metastasis suppression through regulation of PI3K/AKT signaling at endosomes
The phosphatases PTEN and INPP4B have been proposed to act as tumor suppressors by antagonizing PI3K/AKT signaling, and are frequently dysregulated in human cancer. While PTEN has been extensively studied, little is known about the underlying mechanisms by which INPP4B exerts its tumor suppressive f...
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| Publicado no: | Cancer Discov |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4497843/ https://ncbi.nlm.nih.gov/pubmed/25883022 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-1347 |
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