In vivo role of INPP4B in tumor and metastasis suppression through regulation of PI3K/AKT signaling at endosomes

The phosphatases PTEN and INPP4B have been proposed to act as tumor suppressors by antagonizing PI3K/AKT signaling, and are frequently dysregulated in human cancer. While PTEN has been extensively studied, little is known about the underlying mechanisms by which INPP4B exerts its tumor suppressive f...

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Bibliographic Details
Published in:Cancer Discov
Main Authors: Chew, Chen Li, Lunardi, Andrea, Gulluni, Federico, Ruan, Daniel T., Chen, Ming, Salmena, Leonardo, Nishino, Michiya, Papa, Antonella, Ng, Christopher, Fung, Jacqueline, Clohessy, John G., Sasaki, Junko, Sasaki, Takehiko, Bronson, Roderick T., Hirsch, Emilio, Pandolfi, Pier Paolo
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497843/
https://ncbi.nlm.nih.gov/pubmed/25883022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-1347
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