NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease

Cytoplasmic nucleophosmin (NPMc+) mutations and FMS-like tyrosine kinase 3 (FLT3) internal tandem duplication (ITD) mutations are two of the most common known molecular alterations in acute myeloid leukemia (AML), and they frequently occur together suggesting cooperative leukemogenesis. To explore t...

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Detalhes bibliográficos
Main Authors: Rau, Rachel, Magoon, Daniel, Greenblatt, Sarah, Li, Li, Annesley, Colleen, Duffield, Amy S., Huso, David, McIntyre, Emily, Clohessy, John G., Reschke, Markus, Pandolfi, Pier Paolo, Small, Donald, Brown, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932758/
https://ncbi.nlm.nih.gov/pubmed/24184354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2013.10.005
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