FLT3/D835Y mutation knock-in mice display less aggressive disease compared with FLT3/internal tandem duplication (ITD) mice

FMS-like tyrosine kinase 3 (FLT3) is mutated in approximately one third of acute myeloid leukemia cases. The most common FLT3 mutations in acute myeloid leukemia are internal tandem duplication (ITD) mutations in the juxtamembrane domain (23%) and point mutations in the tyrosine kinase domain (10%)....

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Hlavní autoři: Bailey, Emily, Li, Li, Duffield, Amy S., Ma, Hayley S., Huso, David L., Small, Don
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2013
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3876267/
https://ncbi.nlm.nih.gov/pubmed/24255108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1310559110
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