FLT3-ITD Knock-in Impairs Hematopoietic Stem Cell Quiescence/Homeostasis, Leading to Myeloproliferative Neoplasm

Internal tandem duplication (ITD) mutations within the FMS-Like Tyrosine Kinase gene (FLT3) render the receptor constitutively active, driving proliferation and survival in leukemic blasts. Expression of Flt3-ITD from the endogenous promoter in a murine knock-in model results in progenitor expansion...

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Detaylı Bibliyografya
Asıl Yazarlar: Chu, S. Haihua, Heiser, Diane, Li, Li, Kaplan, Ian, Collector, Michael, Huso, David, Sharkis, Saul J, Civin, Curt, Small, Don
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725984/
https://ncbi.nlm.nih.gov/pubmed/22958930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2012.05.027
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