Differential requirement of mTOR in post-mitotic tissues and tumorigenesis

The mammalian target of rapamycin (mTOR) is a crucial effector in a complex signaling network commonly disrupted in cancer. mTOR exerts its multiple functions in the context of two different multiprotein complexes: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). Loss of the tumor suppressor PTE...

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Autores principales: Nardella, Caterina, Carracedo, Arkaitz, Alimonti, Andrea, Hobbs, Robin M., Clohessy, John G., Chen, Zhenbang, Egia, Ainara, Fornari, Alessandro, Fiorentino, Michelangelo, Loda, Massimo, Kozma, Sara C., Thomas, George, Cordon-Cardo, Carlos, Pandolfi, Pier Paolo
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906144/
https://ncbi.nlm.nih.gov/pubmed/19176516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000189
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