Calling on the cancer sleuths: how cell biologists will do the detective legwork of the postcancer genome era

Por Trotman, Lloyd C.
Publicado em 2011

PTEN Plasticity - How the Taming of a Lethal Gene Can Go too Far

Por Naguib, Adam, Trotman, Lloyd C.
Publicado em 2013

Competence against insufficiency: Why are men mostly safe from a rare and deadly prostate cancer?

Por Mathew, Grinu, Trotman, Lloyd C.
Publicado no J Exp Med (2020)

Turning Off AKT: PHLPP as a Drug Target

Por Newton, Alexandra C., Trotman, Lloyd C.
Publicado em 2014

PTEN: Bridging Endocytosis and Signaling

Por Lee, Matthew F., Trotman, Lloyd C.
Publicado no Cold Spring Harb Perspect Med (2020)

Molecular Pathways: PI 3-Kinase Pathway Phosphatases as Biomarkers for Cancer Prognosis and Therapy

Por Chen, Muhan, Nowak, Dawid G., Trotman, Lloyd C.
Publicado em 2014

Nuclear Targeting of Adenovirus Type 2 Requires CRM1-mediated Nuclear Export

Por Strunze, Sten, Trotman, Lloyd C., Boucke, Karin, Greber, Urs F.
Publicado em 2005

PTEN Regulation of Local and Long-Range Connections in Mouse Auditory Cortex

Por Xiong, Qiaojie, Oviedo, Hysell V., Trotman, Lloyd C., Zador, Anthony M.
Publicado em 2012

Rapid in vivo validation of candidate drivers derived from the PTEN-mutant prostate metastasis genome

Por Cho, Hyejin, Stahlhut, Carlos, Herzka, Tali, Watrud, Kaitlin, Robinson, Brian D., Trotman, Lloyd C.
Publicado no Methods (2015)

Identification of a tumour suppressor network opposing nuclear Akt function

Por Trotman, Lloyd C., Alimonti, Andrea, Scaglioni, Pier Paolo, Koutcher, Jason A., Cordon-Cardo, Carlos, Pandolfi, Pier Paolo
Publicado em 2006

Prostate cancer genetic-susceptibility locus on chromosome 20q13 is androgen receptor-regulated and amplified in metastatic tumors

Por Labbé, David P., Nowak, Dawid G., Deblois, Geneviève, Lessard, Laurent, Giguère, Vincent, Trotman, Lloyd C., Tremblay, Michel L.
Publicado em 2013

Mutations in p53 change phosphatidylinositol acyl chain composition

Por Naguib, Adam, Bencze, Gyula, Engle, Dannielle, Chio, Iok I. C., Herzka, Tali, Watrud, Kaitlin, Bencze, Szilvia, Tuveson, David A., Pappin, Darryl J, Trotman, Lloyd C.
Publicado no Cell Rep (2014)

Rapid and tunable method to temporally control gene editing based on conditional Cas9 stabilization

Por Senturk, Serif, Shirole, Nitin H., Nowak, Dawid G., Corbo, Vincenzo, Pal, Debjani, Vaughan, Alexander, Tuveson, David A., Trotman, Lloyd C., Kinney, Justin B., Sordella, Raffaella
Publicado no Nat Commun (2017)

RapidCaP, a novel GEM model for analysis and therapy of metastatic prostate cancer reveals Myc as a driver of Pten-mutant metastasis

Por Cho, Hyejin, Herzka, Tali, Zheng, Wu, Qi, Jun, Wilkinson, John E., Bradner, James E., Robinson, Brian D., Castillo-Martin, Mireia, Cordon-Cardo, Carlos, Trotman, Lloyd C.
Publicado em 2014

PTP1B deficiency enables the ability of a high fat diet to drive the invasive character of PTEN-deficient prostate cancers

Por Labbé, David P., Uetani, Noriko, Vinette, Valérie, Lessard, Laurent, Aubry, Isabelle, Migon, Eva, Sirois, Jacinthe, Haigh, Jody J., Bégin, Louis R., Trotman, Lloyd C., Paquet, Marilène, Tremblay, Michel L.
Publicado no Cancer Res (2016)

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

Por Chen, Zhenbang, Trotman, Lloyd C., Shaffer, David, Lin, Hui-Kuan, Dotan, Zohar A., Niki, Masaru, Koutcher, Jason A., Scher, Howard I., Ludwig, Thomas, Gerald, William, Cordon-Cardo, Carlos, Pandolfi, Pier Paolo
Publicado em 2005

Subtle variations in Pten dose determine cancer susceptibility

Por Alimonti, Andrea, Carracedo, Arkaitz, Clohessy, John G, Trotman, Lloyd C, Nardella, Caterina, Egia, Ainara, Salmena, Leonardo, Sampieri, Katia, Haveman, William J, Brogi, Edi, Richardson, Andrea L, Zhang, Jiangwen, Pandolfi, Pier Paolo
Publicado em 2010

Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output

Por Reyes, Gloria, Niederst, Matt, Cohen-Katsenelson, Ksenya, Stender, Joshua D., Kunkel, Maya T., Chen, Muhan, Brognard, John, Sierecki, Emma, Gao, Tianyan, Nowak, Dawid G., Trotman, Lloyd C., Glass, Christopher K., Newton, Alexandra C.
Publicado em 2014

Pten Dose Dictates Cancer Progression in the Prostate

Por Trotman, Lloyd C, Niki, Masaru, Dotan, Zohar A, Koutcher, Jason A, Di Cristofano, Antonio, Xiao, Andrew, Khoo, Alan S, Roy-Burman, Pradip, Greenberg, Norman M, Dyke, Terry Van, Cordon-Cardo, Carlos, Pandolfi, Pier Paolo
Publicado em 2003

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

Por Alimonti, Andrea, Nardella, Caterina, Chen, Zhenbang, Clohessy, John G., Carracedo, Arkaitz, Trotman, Lloyd C., Cheng, Ke, Varmeh, Shohreh, Kozma, Sara C., Thomas, George, Rosivatz, Erika, Woscholski, Rudiger, Cognetti, Francesco, Scher, Howard I., Pandolfi, Pier Paolo
Publicado em 2010