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RapidCaP, a novel GEM model for analysis and therapy of metastatic prostate cancer reveals Myc as a driver of Pten-mutant metastasis
Genetically Engineered Mouse (GEM) models are a pillar of functional cancer research. Here we developed RapidCaP, a GEM modeling system that uses surgical injection for viral gene delivery to prostate. We show that in Pten-deficiency, loss of p53 suffices to trigger metastasis to distant sites at gr...
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Main Authors: | , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4084646/ https://ncbi.nlm.nih.gov/pubmed/24444712 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-13-0346 |
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