Myc drives Pten/p53-deficient proliferation and metastasis due to Il6-secretion and Akt-suppression via Phlpp2

We have recently recapitulated metastasis of human PTEN/TP53-mutant PC in mouse using the RapidCaP system. Surprisingly, we found that this metastasis is driven by Myc-, and not Akt-activation. Here, we show that cell-cell communication by Il6 drives the Akt-Myc switch through activation of the Akt-...

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Publicado no:Cancer Discov
Main Authors: Nowak, Dawid G., Cho, Hyejin, Herzka, Tali, Watrud, Kaitlin, DeMarco, Daniel V., Wang, Victoria M. Y., Senturk, Serif, Fellmann, Christof, Ding, David, Beinortas, Tumas, Kleinman, David, Chen, Muhan, Sordella, Raffaella, Wilkinson, John E., Castillo-Martin, Mireia, Cordon-Cardo, Carlos, Robinson, Brian D., Trotman, Lloyd C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4456272/
https://ncbi.nlm.nih.gov/pubmed/25829425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-1113
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